Before Starting Any Treatment

1-Non-segmental vitiligo (NSV) is a symptom of something wrong that is happening inside your body. Despite this basic understanding, many Doctors still say it's an autoimmune disease. New research is moving forward in a different direction. It's also becoming clear that NSV doesn't cause any inflammation, but inflammation may actually cause NSV.

2-It's only triggered in people that has genetic predisposition (either inheritance mechanisms or fetal DNA formation). This is the Primary Cause.

3-One or more systematic Secondary Causes have to be present as well. These include: oxidative stress, physical trauma/friction, and psychological/emotional systematic (not severe) stress.

4-This genetic predisposition can be triggered by an internal or external severe (not systematic) event with any of the following facets: physical, emotional, psychological, or environmental.

5-The following list is a mandatory pre-checking list of related issues that might be present in a vitiligo patient (a Doctor should be consulted to determine if the patient suffers one of more of these conditions). However, these usually trigger different types of vitiligo, other than NSV.


•Hashimoto disease

•Celiac disease

•Adrenal fatigue

•Liver toxicity

•Lead contamination

Functional Treatment Suggestion

You can start treating vitiligo from the outside (skin) at any time, however it might be a waste of time and money if you don't address/check yourself against the list at point 5 (above) and if you don't follow a comprehensive Functional Treatment regimen. After making sure that conditions at point 5 have been ruled out or fixed, it will be time to commence a Functional Treatment plan.

Functional Medicine addresses the underlying causes of disease, using a systems-oriented approach and engaging both patient and practitioner in a therapeutic partnership. It is an evolution in the practice of medicine that better addresses the healthcare needs of the 21st century. By shifting the traditional disease-centered focus of medical practice to a more patient-centered approach, functional medicine addresses the whole person, not just an isolated set of symptoms. Functional medicine practitioners spend time with their patients, listening to their histories and looking at the interactions among genetic, environmental, and lifestyle factors that can influence long-term health and complex, chronic disease. In this way, functional medicine supports the unique expression of health and vitality for each individual.

A good Functional Treatment has to combine a lot of actions, ALL AT THE SAME TIME. For instance: avoiding physical traumas and friction, balancing psychological and emotional issues, changing lifestyle, following an UVB-NB phototherapy, taking nutritional supplementation, reducing oxidative stress by taking anti-oxidants and anti-fungals, applying topical creams (Elidel, Protopic and Pseudocatalase), and also following a good diet if necessary (e.g., gluten-free, dairy-free).


•Physical trauma means: systematic friction, injuries, itches, scratches, allergies, sun burns, impacts, violent moves, hits, punches, kicks, etc.

•Oxidative stress means excess of free radicals. It's mainly caused by food allergy, poor diet, leaky gut and dysbiosis (parasites, candida, h-pylori, yeast, fungus, etc.). Oxidative stress can be reduced by taking anti-oxidant and anti-fungal pills.

•Systematic psychological and emotional behaviors and/or feelings, as follows:

→ if you are a person who is feeling completely out of place;

→ you feel that you are no one in the group or you have no sense of belonging;

→ if you are a "yes-but" person;

→ if you are never satisfied with what you have / how you look / what you are;

→ if you feel that there is lack of joy in your life, etc.

•A good lifestyle aims will result in the production of less stress hormones, which plays a big role in keeping vitiligo at bay. More about stress hormones...

•UVB-NB improves cell adhesion, so that melanocyte integrin gains strength, as well as stimulates melanocyte stem cell production in the hair follicle areas of the skin.

•Nutritional supplementation includes vitamins, minerals and trace nutrients.

•Elidel and Protopic have a moderate success in "fighting" against MIA (not neutralizing it). As noted on the home page, the exact way these work is not known, but it seems that they help detached melanocytes to reatach to the basal membrane, by keeping immune system away.

•Pseudocatalase breaks down harmful hydrogen peroxide accumulated in the skin follicles by oxidative stress and converts it into water and oxygen. Hydrogen peroxide causes vacuolation in epidermal melanocytes and keratinocytes, as well as lipid peroxidation, mitochondrial DNA mutation and unbalance of epidermal dehydratase activities.

•It is always necessary to consider diet, but it is mandatory if an issue is confirmed by an allergy test.

•Last but not least, all the items above aim to stop vitiligo spreading. Whilst the patches of vitiligo may shrink remember that whenever MIA is present, melanocytes adhesion (integrin) will be a permanent target. Dr. Matteo Bordignon is actually trying to develop a cure based on the inhibition of this MIA protein. We really hope it will be available as soon as possible (

FUNCTIONAL TREATMENT PROTOCOL (dosages should be discussed with your Doctor):

1- 9W UVB-NB Phototherapy 3x a week (expose each patch separately)

2- Daily Supplementation Suggestion:

• Vitamin C (By GNC) ⇒ 50mg

• Vitamin K (by GNC) ⇒ 10mcg

• Vitamin E (by GNC) ⇒ 200IU

• Vitamin D3 Cholecalciferol (by GNC) ⇒ 2000IU

• Beta Carotene plus mix of carotenoids (by Pure Encapsulations) ⇒ 25000IU

• Complex-B (by GNC)

→ B1 Thiamine ⇒ 15mg

→ B2 Riboflavin ⇒ 20mg

→ B3 Niacin ⇒ 25mg

→ B5 Pantothenic Acid ⇒ 50mg

→ B6 ⇒ 25mg

→ Biotin ⇒ 300mcg

→ B12 ⇒ 250mcg

→ Folate ⇒ 400mcg

• Fish Oil - Omega 3 (any mercury-free brand) ⇒ 1000mg

• Selenium (by GNC) ⇒ 100mcg

• Zinc (by GNC) ⇒ 20mg

• Copper (by GNC) ⇒ 2mg

• Calcium (By GNC) ⇒ 500mg

• Magnesium (by GNC) ⇒ 300mg

• Iodine (by GNC) ⇒ 80mcg

• Manganese (by GNC) ⇒ 2mg

• Chromium ⇒ 100mcg

• Molybdenum ⇒ 25mcg

• Vanadium ⇒ 15mcg

• Inositol ⇒ 80mg

• Lutein ⇒ 1mg

• Boron ⇒ 1mg

• Silicon Dioxide ⇒ 2mg

• Choline Bitartrate ⇒ 80mg

• L-Tyrosine ⇒ 300mg

• Bioperine ⇒ 10mg

3- Daily Anti-Oxidant Suggestion:

• R Lipoic Acid (stabilized) or ALA (by Pure Encapsulations) ⇒ 100mg

• L-Glutammine Powder (by Nutrabio) ⇒ 3g

• L-Cysteine Powder ou N-Acetyl Cysteine (by Nutrabio) ⇒ 600mg

• L-Methionine Powder (by Nutrabio) ⇒ 375mg

• Grape Seed (by GNC) ⇒ 100mg

4- Daily Anti-Fungal Suggestion:

• Probiotics (by Hyperbiotics, e.g. PRO-15) ⇒ 1 capsule with at least 5 billion CFU of the beneficial bacteria

The next 3 items should be taken until the bottle ends:

• Paracid Forte (by Ortho Molecular) ⇒ 1 capsule at least 4 hours before or after any Probiotics, in order to kill parasites

• Formula SF722 (by Thorne Research) ⇒ 1 capsule in order to optimize gastrointestinal tract functioning

• MetalloClear (by Metagenics) ⇒ 1 capsule in order to detox heavy metal

5- Topical Creams:

• Protopic 2x a day on face patches.

• Elidel 1x a day on the other patches.

• Apply Pseudocatalase 2x a day (before 9AM and after 5PM). After application, wait 15 minutes and then take a 10 minute sun bath or 30 second UVB-NB phototherapy session (talk to a doctor before undertaking any phototherapy). Avoid Pseudocatalase cream on the spots that are being treated with Protopic (use only one or the other).

6- Drink a 8 oz of green juice daily (green apple or kiwi, spinach, celery, cucumber, collard, watercress, and kale).

7- If you are not able to do a food allergy test, you should at the minimum follow a gluten-free diet.

• Suggestion for a single day:

→ Breakfast: Coconut milk, 2 slices of gluten-free bread with tahini, 1 banana and/or 1 apple.

→ Lunch: Gluten-free rice, black beans, wild caught fish, carrots, cucumber, lettuce, backed sweet potato, and olive oil.

→ Snack: Coconut milk, 2 slices of gluten-free bread with organic honey, and a green juice (kiwi, spinach, celery, collard, watercress, and kale).

→ Dinner: Gluten-free brown rice, green beans, hormone-less chicken, carrots, lettuce, pumpkin, and olive oil.

→ In-between: A lot of water (mineral, spring, purified). Avoid tap water since it may contain chlorine, fluoride, etc.

8- Regarding life style, try to add yoga to your daily life in order to help you de-strress. Remember not to add any high impact activity.

Keep in Mind on a Daily Basis

Assuming that you have checked yourself against the mandatory pre-checking list (at point 5 above in "Before Starting Any Treatment" section) and addressed any issues, and also assuming you are following a Functional Treatment regimen, you must be vigilant in addressing the main causes as detailed below. These factors will affect you on a daily basis:

1-Physical traumas ⇒ friction, injuries, itches, scratches, allergies, sun burns, impacts, violent moves, hits, punches, kicks, etc.

2-Oxidative stress ⇒ food allergy, poor diet, leaky gut and dysbiosis (parasites, candida, h-pylori, yeast, fungus, etc.). Effects are lipid peroxidation, hydrogen peroxide, ROS, and mitochondrial DNA mutation.

3-Stress hormones ⇒ generated by psychological and emotional systematic stress.

All together, these stimulate the generation of MIA that detaches melanocytes and cause white patches. So, avoid them!